Synvisc-One

Hyaluronic Acid Injection for Knee Osteoarthritis

Synvisc-One is a single-injection treatment for knee osteoarthritis. It is a clear gel made from a natural substance that lubricates the joint, temporarily replacing deteriorated synovial fluid. It may provide up to 6 months of pain relief per injection and can improve mobility.

Synvisc-One Injection

What is Synvisc-One?

In knees with osteoarthritis, the joint fluid (called synovial fluid) can break down and not provide the cushioning your knee needs.
A. Cartilage wears away B. Bone spurs may develop C. Joint fluid breaks down
Synvisc-One supplements your knee joint fluid to relieve the pain and improve the knee joint's natural shock absorbing abilities.
D. Synvisc-One replaces joint fluid

Frequently Asked Questions

Who is it for?

Patients with knee osteoarthritis who have tried diet, exercise, and over-the-counter pain relief but still experience symptoms.

  • Given as a single, in-clinic injection.
  • Dr Ibrahim’s protocol: injections every 6 months for 2 years, then yearly.
  • Relief can start within a month; full benefits usually 8-12 weeks after the treatment course.
  • Efficacy can last up to 12 months.
  • Rest for at least 24 hours post-injection.
  • Avoid strenuous activity for 48 hours.
  • Some patients may experience temporary knee pain or swelling (synovitic reaction).
  • Usually mild; about 3.4% of patients report local adverse effects.
  • Patients with allergies to bird products may not be suitable.
  • $480-$550 per injection (GST inclusive).
  • Chevalier et al., Ann Rheum Dis., 2010
  • Waddell & Bricker, J Surg Orthop Adv., 2006

Articles

Optimising PRP Outcomes in Knee Osteoarthritis

Optimising nutrition—particularly collagen, vitamin C, and an anti-inflammatory diet—may support healing and enhance outcomes following PRP treatment for knee osteoarthritis.

Why total platelet dose matters?

Across recent syntheses and expert reviews, higher total platelet numbers delivered to the joint are associated with better clinical outcomes, particularly for function and durability of effect.

Comparing PRP with Corticosteroids and Hyaluronic Acid (HA)

Intra-articular injections commonly include corticosteroids, hyaluronic acid (viscosupplementation), or newer biologics including PRP. Understanding relative efficacy, durability, and safety is key to choosing among them.